• 목록
• 답변
• 글쓰기
• 게시판 리스트 옵션
  • 수정
  • 삭제

Myelodysplastic Syndrome Injury

The bone marrow (the spongy tissue that produces blood cells) produces too few mature white blood cells as well as red blood cells and platelets. This condition is known as myelodysplastic Syndrome, or MDS.

Your blood stem cells ought to develop into healthy blood cells before leaving your bone marrow for the bloodstream. In MDS however, the cells that are not mature are able to block healthy cells.

Signs and symptoms

The bone the marrow is a soft tissue inside bones that produces blood-forming cells. The cells eventually transform into red blood cells white blood cells, as well as platelets. They are then released into the bloodstream, which circulates throughout the body and perform crucial functions. For example red blood cells supply oxygen and white blood cells fight infection and platelets assist in stopping bleeding by forming blood vessels at the site of injury.

When the blood-forming cells in the bone marrow have been found to be abnormal this can result in lower numbers of healthy blood cells within the body. The signs and symptoms will depend on the blood cell types are affected.

MDS can cause symptoms such as anemia, thrombocytopenia and chromosomal abnormalities in the bone marrow. The World Health Organization categorizes MDS into six types. Certain kinds of MDS have a higher likelihood of progressing to acute myeloid lymphoma (AML) than other types.

Every type of Myelodysplastic Syndrome railroad cancer settlements disorder has its own distinct genes and molecules that trigger the disease. Hematologists, radiation oncologists, and biologic and molecular pathologists work together at OSUCCC-James to develop individualized treatment plans for every patient. This team approach ensures the best possible treatment and care is offered for many blood and bone marrow disorders. We also provide access the nation's most advanced clinical trials right here at OSUCCC - James.

Diagnosis

It is important to visit your physician immediately if you suspect that you have a Myelodysplastic Syndrome cancer settlement condition. Your doctor will check your symptoms and do tests that look for cancerous cells in your blood and bone marrow.

The diagnosis is based on the amount and type of abnormal blood cells your doctor finds. The diagnosis is also based on if your cells are affected by a specific mutation in their DNA. There are four different types of Myelodysplastic Syndrome lawsuit settlements disorders. The most well-known type is MDS with multilineage dysplasia, or MDS-MLD. It means that more than 10 percent of two or more types of blood cellsincluding red blood cells, platelets and white blood cell are malformed or have a DNA alteration that's characteristic of MDS-MLD. MDS-del-5q is a different type of MDS. It's also known as MDS with isolated 5q chromosome abnormality. This signifies that you have fewer blood cells than normal and that your cells are missing a portion of a cell's chromosome.

MDS with erythrocyte prototoporphyrin (MDS EPI) and MDS with acquired somatic mutations of ATRX (MDS ATRX) are less frequent types. These subtypes are more difficult to treat than MDS-5q or MDS-5q-MLD.

Treatment

The various types of Myelodysplastic syndrome are classified based on the changes they trigger in your blood cells as well as bone marrow (the sponge-like substance within your bones that creates your blood cells). Your doctor will determine the best treatment for you. Treatments are typically designed to ease symptoms, prevent complications, and slow down or ease the condition.

Your blood cells - including red blood cells white blood cells, red blood cells, and platelets -- develop from stem cells in your bone marrow. If you suffer from MDS the blood cells that are immature (blasts) aren't healthy red blood cells or white blood cells, or work as platelets. The blasts will die within the bone marrow, or within a short time after entering your bloodstream. This leaves you with a lack of healthy cells. Certain types of MDS can eventually turn into leukemia.

Certain medications can cause MDS particularly when they are taken for a long period or Myelodysplastic Syndrome injury in high doses. These include chemotherapies, steroids, antibiotics, drugs used to treat infection and cancer, such as the treatment for leukemia and methotrexate and certain vitamins. Your doctor will let you know whether any of your medications may be causing your MDS. If they are, your doctor can reduce or stop your dose. Other treatments can help reduce your symptoms, such as erythropoietin-stimulating agents, which increase the number of mature red blood cells and lessen your need for blood transfusions; and granulocyte colony-stimulating factors.

Prevention

In the bone marrow, stem cells (immature cells) change into red blood cells, platelets and white blood cells. As the cells mature they leave bone marrow to enter your bloodstream. When they circulate, blood cells provide oxygen to tissues in your body, fight infection and clot when you cut yourself.

In myelodysplastic syndromes stem cells aren't maturing properly and they don't leave bone marrow in a normal way. This decreases the number of healthy blood cells in the bloodstream, which increases your risk of developing serious health issues.

The treatment for myelodysplastic disorders is dependent on the type of cells are affected and how low their numbers are. Treatment typically includes chemotherapy. This drug therapy eliminates cancerous cells, but it also destroys healthy cells that can't regenerate. The treatment is usually followed by stem cell transplantation. In this type of treatment, blood-forming cells are removed from your body or a donor and then returned to you through an infusion.