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Multiple Myeloma and Csx Transportation
Peter worked at the Long Island Railroad Company for 29 years. Through that time the worker was exposed to numerous hazardous chemicals. These chemicals and substances included diesel fumes creosote, welding fumes, csx transportation mesothelioma and dust.
Multiple myeloma affects the plasma cells, which produce antibodies to fight diseases and infections. These cancerous cells develop in bones, and form cancerous tumors known as plasmacytomas.
Signs and symptoms
The cancer targets the plasma cells that create antibodies that aid the body in fighting germs and infections. Symptoms of multiple myeloma can include bone pain, particularly in the back or ribs; bones that are brittle that break easily and fatigue; weakness; loss of appetite; kidney problems with high levels calcium in blood (hypercalcemia) and infections.
Often, myeloma does not cause symptoms until its early stages. In fact, doctors may only find it out following a routine examination for a different disease reveals more protein in blood or urine than normal. This is referred to as smoldering myeloma. In the later stages, myeloma might cause damage to organs such as the kidneys and lungs, as well as the nervous system, which could cause problems with balance and vision.
Your outlook is affected by the stage of your myeloma as well as other health conditions and also your age at the time of diagnosis. Your outlook is also affected by the amount of plasma cells are producing tumors and creating complications and also the genetic factors that affect your risk of developing myeloma.
People with a chromosomal anomaly known as deletion 17p or duplication 18q, have a poorer outlook than those without these anomalies. Kidney function is also crucial: if your kidneys aren't functioning in a similar way, you will have a poorer outlook. The level of creatinine is a good indication of how well your kidneys function.
Diagnosis
Multiple myeloma gets diagnosed when the patient's urine or blood is analyzed for a different illness and an over-the-top amount of protein is identified. Symptoms of myeloma include bone pain; weakness of the bones, including the ribs and back kidney problems and a fever with no known reason; bruising or bleeding easily; and difficulties breathing.
The disease is more prevalent in people who are older and is most often seen in men over 60. Myeloma is more frequent in people with relatives of the first degree. Their risk of getting the disease is 2 to 3 times greater than other people. This includes parents and siblings as well as children.
There are a variety of risk factors for myeloma. They include a previous diagnosis of a single, solitary plasmacytoma within the bone or extramedullary plasmacytoma of soft tissue (such as the throat or lung). People who have been exposed to radiation or certain chemicals, like asbestos, benzene, and pesticides, Csx transportation Mesothelioma are more at risk for myeloma. People who have high levels of monoclonal gammopathy with undetermined significance (MGUS) in the blood are at greater risk of developing myeloma too.
Two toxicologists and one epidemiologist were the plaintiffs' expert witness. Toxicology is a science that investigates the way in which a substance could be harmful and the way exposure can cause the development of a disease. Epidemiology is the study of factors that cause and affect diseases like myeloma by studying statistics and medical records.
Treatment
The treatment for myeloma has been based on radiation and chemotherapy. There are a variety of chemotherapy drugs available. There is also a brand new class of drugs called monoclonal antibody that can kill myeloma cells. Daratumumab Elotuzumab, Daratumumab, and others are among them. Combining these medications with other treatments improves the outcome. Other treatments include transplants stem therapy, immunotherapies and the use of cellular vaccines.
While myeloma can affect people of any age, certain factors increase the chance of getting the disease. Those who are older than 45 are at higher risk and so are those who have a family history of myeloma. People who have been exposed to radiation or chemicals are also at higher risk. This includes those who have been exposed to Xrays, and those who worked in industries that employ benzene, asbestos, and herbicides such as Agent Orange.
Ronald Harris died in 2013 from multiple myeloma. His estate filed a lawsuit against CSX Transportation claiming that his job as a railroad worker was the cause of his cancer. The trial court held an evidentiary hearing to listen to the testimony of three plaintiffs' experts in science: Dr. Goldstein and Dr. Infante. They used proven methods to show that CSX diesel exhaust fumes exposure resulted in Harris myeloma. The evidence of the expert witness was built on animal and human studies as well as the chemical makeup of diesel exhaust as well as closely related pyrogenic materials, as well as studies on B-lymphocytes.
Prognosis
Multiple myeloma is an illness that affects plasma cells. These cells are crucial to the immune system, as they help the body fight off illnesses and infections. In people with myeloma, plasma cells begin to expand beyond their limits and can obstruct normal bone marrow. This can lead to other health problems, including low blood counts and bone damage.
Multiple myeloma is more prone to be diagnosed if someone has a number of risk factors. The age of the person, their family history, and exposure to radiation and certain chemicals are all risk factors. A first-degree relative suffering from multiple myeloma is twice as likely to develop it by themselves. Myeloma also occurs more often in black people than white people.
Ronald Harris was a railroad trainman for csx transportation mesothelioma Transportation. He worked there for 29 years. He was regularly exposed to diesel exhaust from locomotives. During his employment, Harris developed multiple myeloma. It is a form of cancer that attacks plasma cells in the bone marrow. Harris filed a lawsuit against CSX under the Federal Employers' Liability Act and Locomotive Inspector Act. Harris tragically passed away while the case was in limbo. His wife, Deborah Kay Harris, was appointed plaintiff.
The petitioner enlisted Dr. Peter Shields as an expert witness in the trial. During the two-day trial, both experts testified about their background and the method they used to render their opinions. Both experts relied on the Bradford Hill methodology.
Peter worked at the Long Island Railroad Company for 29 years. Through that time the worker was exposed to numerous hazardous chemicals. These chemicals and substances included diesel fumes creosote, welding fumes, csx transportation mesothelioma and dust.
Multiple myeloma affects the plasma cells, which produce antibodies to fight diseases and infections. These cancerous cells develop in bones, and form cancerous tumors known as plasmacytomas.
Signs and symptoms
The cancer targets the plasma cells that create antibodies that aid the body in fighting germs and infections. Symptoms of multiple myeloma can include bone pain, particularly in the back or ribs; bones that are brittle that break easily and fatigue; weakness; loss of appetite; kidney problems with high levels calcium in blood (hypercalcemia) and infections.
Often, myeloma does not cause symptoms until its early stages. In fact, doctors may only find it out following a routine examination for a different disease reveals more protein in blood or urine than normal. This is referred to as smoldering myeloma. In the later stages, myeloma might cause damage to organs such as the kidneys and lungs, as well as the nervous system, which could cause problems with balance and vision.
Your outlook is affected by the stage of your myeloma as well as other health conditions and also your age at the time of diagnosis. Your outlook is also affected by the amount of plasma cells are producing tumors and creating complications and also the genetic factors that affect your risk of developing myeloma.
People with a chromosomal anomaly known as deletion 17p or duplication 18q, have a poorer outlook than those without these anomalies. Kidney function is also crucial: if your kidneys aren't functioning in a similar way, you will have a poorer outlook. The level of creatinine is a good indication of how well your kidneys function.
Diagnosis
Multiple myeloma gets diagnosed when the patient's urine or blood is analyzed for a different illness and an over-the-top amount of protein is identified. Symptoms of myeloma include bone pain; weakness of the bones, including the ribs and back kidney problems and a fever with no known reason; bruising or bleeding easily; and difficulties breathing.
The disease is more prevalent in people who are older and is most often seen in men over 60. Myeloma is more frequent in people with relatives of the first degree. Their risk of getting the disease is 2 to 3 times greater than other people. This includes parents and siblings as well as children.
There are a variety of risk factors for myeloma. They include a previous diagnosis of a single, solitary plasmacytoma within the bone or extramedullary plasmacytoma of soft tissue (such as the throat or lung). People who have been exposed to radiation or certain chemicals, like asbestos, benzene, and pesticides, Csx transportation Mesothelioma are more at risk for myeloma. People who have high levels of monoclonal gammopathy with undetermined significance (MGUS) in the blood are at greater risk of developing myeloma too.
Two toxicologists and one epidemiologist were the plaintiffs' expert witness. Toxicology is a science that investigates the way in which a substance could be harmful and the way exposure can cause the development of a disease. Epidemiology is the study of factors that cause and affect diseases like myeloma by studying statistics and medical records.
Treatment
The treatment for myeloma has been based on radiation and chemotherapy. There are a variety of chemotherapy drugs available. There is also a brand new class of drugs called monoclonal antibody that can kill myeloma cells. Daratumumab Elotuzumab, Daratumumab, and others are among them. Combining these medications with other treatments improves the outcome. Other treatments include transplants stem therapy, immunotherapies and the use of cellular vaccines.
While myeloma can affect people of any age, certain factors increase the chance of getting the disease. Those who are older than 45 are at higher risk and so are those who have a family history of myeloma. People who have been exposed to radiation or chemicals are also at higher risk. This includes those who have been exposed to Xrays, and those who worked in industries that employ benzene, asbestos, and herbicides such as Agent Orange.
Ronald Harris died in 2013 from multiple myeloma. His estate filed a lawsuit against CSX Transportation claiming that his job as a railroad worker was the cause of his cancer. The trial court held an evidentiary hearing to listen to the testimony of three plaintiffs' experts in science: Dr. Goldstein and Dr. Infante. They used proven methods to show that CSX diesel exhaust fumes exposure resulted in Harris myeloma. The evidence of the expert witness was built on animal and human studies as well as the chemical makeup of diesel exhaust as well as closely related pyrogenic materials, as well as studies on B-lymphocytes.
Prognosis
Multiple myeloma is an illness that affects plasma cells. These cells are crucial to the immune system, as they help the body fight off illnesses and infections. In people with myeloma, plasma cells begin to expand beyond their limits and can obstruct normal bone marrow. This can lead to other health problems, including low blood counts and bone damage.
Multiple myeloma is more prone to be diagnosed if someone has a number of risk factors. The age of the person, their family history, and exposure to radiation and certain chemicals are all risk factors. A first-degree relative suffering from multiple myeloma is twice as likely to develop it by themselves. Myeloma also occurs more often in black people than white people.
Ronald Harris was a railroad trainman for csx transportation mesothelioma Transportation. He worked there for 29 years. He was regularly exposed to diesel exhaust from locomotives. During his employment, Harris developed multiple myeloma. It is a form of cancer that attacks plasma cells in the bone marrow. Harris filed a lawsuit against CSX under the Federal Employers' Liability Act and Locomotive Inspector Act. Harris tragically passed away while the case was in limbo. His wife, Deborah Kay Harris, was appointed plaintiff.
The petitioner enlisted Dr. Peter Shields as an expert witness in the trial. During the two-day trial, both experts testified about their background and the method they used to render their opinions. Both experts relied on the Bradford Hill methodology.
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